Photos c. Wil Matthews/ZippZipp has often highlighted their Impress Direct-Print technology on various one-off wheelsets, but this might be the best use yet. Not only is Alexander Kristoff a big shot on Team Katusha, but he’s also a native of Stavanger, Norway. What better way to honor his heritage than with a Zipp Super-9 disc disguised as a Viking inspired shield? Granted the choice of material has been upgraded from wood to a much more modern unidirectional carbon fiber…Photos c. Wil Matthews/ZippGiven the fact that the graphics are printed directly onto the carbon, the treatment is super light an more durable than decals. You can see the wheel in person on the stage 6 Individual Time Trial in the Tour of California this Friday. Now, maybe another company can follow up with a sword made of disc brake rotors…zipp.com
Vermont Business Magazine A proposed Rule Governing the Importation of Untreated Firewood into the State of Vermont has been filed with the Secretary of State. The purpose of the rule is to protect forest health by slowing the long-distance movement of wood-borne invasive forest pests, such as Asian longhorned beetle and emerald ash borer, and preventing the spread of pests into Vermont. The enabling legislation requires the Department of Forests, Parks, and Recreation to adopt regulations on importing untreated firewood.The proposed rule, as filed, is open for public comment until January 15, 2016. Two public hearings are scheduled:• Tuesday, January 5th at the Manchester Town Hall in Manchester Center• Thursday, January 7th at the Northeastern Vermont Regional Hospital in St. Johnsbury.Both hearings will begin at 4:00 PM.The proposed rule prohibits the importation of untreated firewood into Vermont. The definition of firewood states that it is wood processed for burning and less than 48 inches in length, but does not include wood chips, pellets, pulpwood, or wood for manufacturing purposes. It allows treated firewood to enter the state if it is treated to the USDA standard of 160° F (71.1° C) for at least 75 minutes at a certified treatment facility and is accompanied by certification of treatment. By written request, the Commissioner of Forests, Parks & Recreation may waive this prohibition under conditions which ensure that the firewood poses minimal threat to forest health. Violations may result in confiscation of firewood and/or a civil citation. The rules are to take effect onMay 1, 2016.For more information on the quarantine and the scheduled hearings, visit: http://fpr.vermont.gov/fpr.vermont.gov/forest/forest_health/health_management/firewood_quarantine(link is external).
Billed as ‘the UK’s fastest long distance triathlon’, Challenge Henley showcases the best of its quintessentially British surroundings. The race features a swim along the Thames Royal Regatta Course, a rolling bike leg on closed roads through the Chiltern Hills and the Pearl Izumi Run Course, which winds its way through the picturesque town of Henley as it follows a path along the River Thames.Pearl Izumi is a leading international brand in the manufacture of high-performance, high-tech sports apparel and footwear for avid cycling, tri and running enthusiasts. Based in Louisville, Colorado, a suburb of Boulder, Pearl Izumi is a wholly owned subsidiary of Shimano American Corporation, located in Irvine, California.www.challengehenley.comwww.pearlizumi.co.uk Related Just Racing, the organiser behind the UK’s Challenge Henley event, has confirmed that Pearl Izumi is now on board as the official Run Sponsor for the 2013 Challenge Henley and Henley Half.The partnership means that thousands of athletes will take to the ‘Pearl Izumi Run Course’ on race day, enjoying the sights and sounds of one of the most beautiful towns in the UK. And of course, throughout the race weekend all athletes and spectators will have the chance to sample and buy Pearl Izumi products at the Challenge Henley expo from the Pearl Izumi retail partner Runner’s Retreat.Just Racing Director Alan Rose said “It’s fantastic to have teamed up with a brand like Pearl Izumi for Challenge Henley. Thousands of athletes and spectators will have the chance to enjoy the Pearl Izumi Run Course, which will once again be one of the highlights of the race.”
A creek running through the Overland Park Arboretum. Opponents of a proposed improvement plan for the arboretum say the city should allow experts to check for the presence of Shawnee tribe artifacts before allowing work to commence. Photo credit Nick Varvel. Used under a Creative Commons License.Overland Park should slow down its plans to expand the arboretum to allow experts to check for artifacts from a band of the Shawnee tribe that formerly lived there, say some of the arboretum’s neighbors.But city officials say the archeological study they had done in 1999 showed no significant cultural artifacts on the grounds. That study said future additions and improvements were unlikely to turn up anything else and that another study shouldn’t be needed. It is unclear whether a separate survey would be needed to say the same about the parts of the arboretum land acquired after that 1999.Opponents of an expansion plan for the Overland Park Arboretum and Botanical Gardens sprung a surprise last week when they called for a delay to survey the property for Native American artifacts. The existence of stone tools, arrowheads and a “language tree” found on surrounding private property should give council members pause about being too quick to start construction, their lawyer told a recent city council meeting.It was the latest twist in an argument between the city and arboretum neighbors that has been simmering for more than a month, as the city council pushed forward plans that have been in the works since 2017.Improvement plans call for new gardens, event spacesA rendering of the proposed arboretum amphitheatre and visitors center.Arboretum officials are touting a long-range plan for new gardens, sculptures, event space and more parking at the site at 179th Street and U.S. Highway 69. First on the construction list would be a bigger visitor center, to take some space pressure off an educational center and gift shop that now serves that purpose. But the plans also call for an outdoor amphitheater with grass seating for 850 that would be created in a natural bowl in the topography. Eventually, a chapel and tropical conservatory also may be added, as donations become available.The plans have drawn opposition of some of the neighbors in subdivisions to the north, who say they support the arboretum and the visitor center but are in full opposition to an amphitheater that they say would make big, loud, traffic-jamming events more frequent.Several of them, from Glad Acres, Wolf Valley and Arbor View subdivisions, have argued against the plans with about 30 signing a protest petition filed with the city, according to neighbor Chengny Thao.Generally, their objections centered on the traffic, noise and lights annoyances that happen during the arboretum’s four large public events. But at the most recent city council meeting, they brought in a new topic – cultural antiquities that may be found in the area.They presented slides of some artifacts that have been found on nearby private land, including stone tools and arrowheads. The presentation also noted a meeting cave and “language tree” that was possibly shaped by Native Americans to point toward water or other natural resources.The neighbors also submitted letters from the Absentee Shawnee Tribe of Oklahoma and the Kansas State Archaeologist recommending a survey of the site to document any cultural significance before the land is disturbed.“It’s in the city’s hands to do the right thing,” Thao said. “If I were the city I would seriously consider it because of the potential for violation of state law.”Kansas law has provisions related to antiquity protectionsKansas’s law basically protects antiquities that are on government-owned land, said Robert Hoard, the state archaeologist. If the arboretum plan looks like it’s going forward, he said he’d likely get in touch with the city to see about doing the assessment.An assessment involves a look around the property and perhaps some light digging with a shovel, Hoard said. The finding of artifacts wouldn’t necessarily stop the project, but it would allow findings to be documented. Any artifacts found during construction would require work to stop while the state and Shawnee Tribe representatives are brought in for consultation.“We try to be very reasonable about enforcement of the law,” while still protecting antiquities, Hoard said.The area is of interest to the Shawnee Tribe because it is on land formerly occupied by the Black Bob Shawnee, according to the tribe’s letter. The Shawnee had reservation land in Kansas in the 1800s before eventually being displaced to Oklahoma.The Overland Park study, done by Don Dycus and Victoria Vargas for the city via George Butler Associates, examined land records and historical archives and included inspection of the property. No artifacts were found by the investigators and they concluded the arboretum development could continue without risk. “It is unlikely that further investigation would identify significant cultural resources,” the study concluded.Dycus and Vargas both had master’s degrees in anthropology and were accredited by the Register of Professional Archeologists to do investigations.The area around the arboretum was less populated when that study was done 20 years ago. In the years since, development has moved farther south, with some under-construction properties near the arboretum now listing for over $700,000. Neighbors in those areas have been particularly troubled by the effect of arboretum events on 179th Street, a two-lane that backs up during big events. City officials insist that they have no plans to introduce any other big public shows that would disturb the quiet of the area.But Thao said she and neighbors will continue to push for more representation and input into the arboretum’s future. “Future litigation is to be determined as we’d like to give the city an opportunity to honor their commitment to being a good neighbor,” she said.“The City Council voted 11 to 1 to approve this measure. If they do not follow Kansas State Preservation laws then those who voted yes should be held accountable for any possible violations as they were fully informed on this matter.”
msnbc:Pigeons may not be so bird-brained after all, as scientists have found the birds’ ability to understand numbers is on par with that of primates.Previous studies have shown that various animals, from honeybees to chimpanzees, can learn to count when trained with food rewards. In 1998, researchers discovered that rhesus monkeys can not only learn to count to four, but can also pick up on numerical rules and apply them to numbers they haven’t seen before, allowing them to count up to nine without further training.With this finding in mind, psychologists at the University of Otago, in New Zealand, sought to find out if pigeons — another animal shown to count — have a numerical competence similar to rhesus monkeys.Read the whole story: msnbc More of our Members in the Media >
The antiviral drug remdesivir had little effect in patients with moderate COVID-19 in 105 hospitals in the United States, Europe, and Asia in a randomized, controlled, open-label trial published late last week in JAMA, adding to a mixed picture of the drug in randomized clinical trials (RCTs), which are considered the gold standard for gauging interventions.Researchers compared the clinical status of 533 coronavirus patients who had moderate pneumonia and were randomly assigned to receive remdesivir for 5 or 10 days or standard care from Mar 15 to Apr 18. Remdesivir was given in a 200-milligram (mg) intravenous dose on the first day, followed by 100 mg a day.After 11 days of treatment, patients in the group receiving remdesivir for 5 days had significantly higher odds of clinical improvement on a 7-point ordinal scale than those in the standard-care group (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.09 to 2.48; P = 0.02). But clinical status was not significantly different between the 10-day remdesivir group and the standard-care group (P = 0.18).Kaplan-Meier estimates of death from any cause at 28 days of treatment were 1% (95% CI, 0.0% to 2.6%) in the 5-day remdesivir group (log-rank P = 0.43 vs standard care), 2% (95% CI, 0.0% to 3.6%) in the 10-day remdesivir group (log-rank P = 0.72 vs standard care), and 2% (95% CI, 0.1% to 4.1%) in the group receiving standard care.Adverse events, clinical outcomesAny differences between the groups receiving remdesivir versus standard care in duration of supplemental oxygen or hospitalization were not significant.Adverse events occurred in 51% of patients in the 5-day remdesivir group, 59% in the 10-day remdesivir group, and 47% in the standard-care group. Nausea was more common in the groups receiving remdesivir than in those receiving standard care (10% vs 3%), as were low blood potassium levels (6% vs 2%) and headache (5% vs 3%).Nine patients had died by day 28, including 4 in the standard-care group, 3 in the 10-day remdesivir group, and 2 in the 5-day remdesivir group. All deaths occurred in patients 64 and older, and none were attributed to remdesivir therapy.Median patient age was 57 years, 39% were women, 56% had cardiovascular disease, 42% had high blood pressure, 40% had diabetes, and 14% had asthma. Median length of remdesivir therapy was 5 days for patients in the 5-day group and 6 days for those in the 10-day group. (Patients who improved enough to be released from the hospital didn’t finish their treatment course.)”Among patients with moderate COVID-19, those randomized to a 10-day course of remdesivir did not have a statistically significant difference in clinical status compared with standard care at 11 days after initiation of treatment,” the authors wrote. “Patients randomized to a 5-day course of remdesivir had a statistically significant difference in clinical status compared with standard care, but the difference was of uncertain clinical importance.”Perplexingly different study outcomesManufactured by Gilead Sciences, remdesivir was granted Emergency Use Authorization by the US Food and Drug Administration for patients 12 years and older with severe COVID-19 on May 20.Two RCTs at that time had compared clinical benefit of a 10-day course of remdesivir with a placebo. The first trial, conducted in Wuhan, China, didn’t find a benefit but had enrolled only 237 patients and may have been underpowered.The second, a US National Institutes of Health study involving 1,063 patients found that patients given remdesivir for 10 days recovered 4 days sooner than those given a placebo, but there was no significant difference in death rate between those who received remdesivir (7.1%) or placebo (11.9%) (hazard ratio, 0.70; 95% CI, 0.47 to 1.04). The current JAMA study was a continuation of that trial.In a JAMA commentary that accompanied the current study, Erin McCreary, PharmD, and Derek Angus, MD, MPH, of the University of Pittsburgh School of Medicine said that the different results of the three RCTs could be partially attributed to study design. They added that future studies should address which patients could benefit the most from remdesivir, how long they should receive it, how they will benefit, and what the relative benefit is in patients who also receive dexamethasone or other corticosteroids.”Some of the RCT findings suggest remdesivir could improve recovery for many millions of individuals around the world who may be hospitalized with COVID-19,” McCreary and Angus wrote. “However, the costs to produce and distribute remdesivir at such scale are considerable, and, most importantly, whether remdesivir offers incremental benefit over corticosteroids, which are widely available and inexpensive, is unknown.” Small study of severe COVID shows promiseIn contrast with the JAMA study, the Journal of Antimicrobial Chemotherapy yesterday published a small retrospective, observational study in Italy that found that remdesivir may have benefitted COVID-19 patients receiving mechanical ventilation.Of 51 COVID-19 patients receiving mechanical ventilation at Pesaro hospital from Feb 29 and Mar 20, 25 received 200 mg of intravenous remdesivir for compassionate use on the first day, followed by 100 mg daily on days 2 to 10. Most patients also received other investigational treatments for the coronavirus, such as hydroxychloroquine (64.7%), lopinavir/ritonavir (56.9%), and tocilizumab (17.6%). Twenty-five patients also required dialysis.The antiviral drug was associated with improved survival (OR, 3.51; 95% CI, 1.77 to 6.95; P < 0.001), and Kaplan-Meier curves demonstrated significantly lower death rates in patients who received remdesivir (56% vs 92%; P < 0.001).The most common underlying conditions were high blood pressure (54.9%), diabetes (13.7%), ischemic heart disease (13.7%), and moderate kidney failure (7.8%).Twenty patients completed 10 days of remdesivir treatment, and five (20%) died of COVID-19 infection at a median of 5 days after starting therapy. At final follow-up, 38 patients (74.5%) had died, 9 (17.6%) had been released from the hospital, and 4 (7.8%) remained hospitalized but no longer needed mechanical ventilation.The authors noted that the study period came at the beginning of the pandemic, when the demand for intensive care unit resources such as ventilators, doctors, and specialized nurses far outstripped the supply, so many patient needs went unmet."In conclusion, in this study the mortality rate of patients with COVID-19 under mechanical ventilation is confirmed to be high," they wrote. "The use of remdesivir was associated with a significant beneficial effect on survival."Observational studies like this one are less valuable than RCTs in assessing a drug and, in fact—as opposed to RCTs—cannot prove that remdesivir actually was the cause of the improved results.
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AdvertisementClick Here to Read MoreAdvertisementASE and the ASE Education Foundation have announced the following staff changes effective Jan. 1. After seven years of leading the Education Foundation, Trish Serratore has decided to transition to part-time status and will move back to ASE as senior vice president of communications. ASE Senior Vice President Mike Coley will take over her position as president of the ASE Education Foundation.A 30-year veteran of ASE, Serratore will be responsible for company communications and will advance awareness about ASE and its value and purpose through industry, consumer and governmental interface.“We are glad to have Trish back on the ASE side. Her longtime experience in the industry and most recently with the Foundation are key to our future initiatives,” said Tim Zilke, ASE president and CEO.Coley has been with ASE for more than 20 years, serving in several capacities, including overseeing the ASE Test Development department. He has both engineering and MBA degrees and previously taught automotive service technology part-time at the local community college.“These changes play to the strengths of our staff. Mike brings a wealth of knowledge and operational experience to the Foundation position,” added Zilke.In other recent staff changes at ASE, Allison Guth, vice president, finance, will now also oversee ASE information technology functions. John Tisdale has been named assistant vice president, special testing programs and Dave Milne has been named assistant vice president, traditional testing programs.AdvertisementFor more information about ASE, visit the website at ase.com.
The Port of Wells dredging scheme is scheduled to commence on the 21th April 2014.The port’s dredger “Kari Hege” will be engaged in dredging operations in the main channel north of number 4 buoy, between buoys 2 and 4.All material dredged from these areas will be placed on the berm which is marked by the port hand channel buoys.The locations which will be dredged are dictated by the regular survey results.[mappress]Press Release, April 18, 2014
Brazil’s Petrobras has completed drilling extension well 3-BRSA-1253D-ESS / 3-ESS-219D (Petrobras nomenclature), informally known as Pudim, at a water depth of 1,886 meters, in the Espírito Santo Basin post-salt.According to Petrobras, the completion of this well, which had been announced on October 7, 2014, confirmed the presence of excellent quality oil through log data analysis, fluid samples and cable test conducted in reservoirs located at a depth of some 4,300 meters. Drilling ended at a depth of 4,670 meters.Then, a cased-hole drill-stem test was conducted at the 4,305 to 4,383 meter interval that confirmed the presence of light oil of approximately 35° API.The well is located in the Brigadeiro Discovery Evaluation Plan (PAD) area, 121 km from the city of Vitória, in Espírito Santo state.Petrobras is the operator (65%) of the consortium responsible for the exploration of the Brigadeiro Discovery Evaluation Plan (PAD), in partnership with PTTEP Brasil Investimentos em Exploração e Produção de Petróleo e Gás Ltda (20%) and Inpex Petróleo Santos Ltda (15%).[mappress mapid=”1015″]